Introduction
Opioid induced constipation ICD 10 coding is critical for accurate billing, clinical communication, and treatment justification in patients undergoing opioid therapy. Affecting nearly 90% of long-term opioid users, opioid-induced constipation (OIC) is a clinically significant adverse drug reaction that must be clearly documented and coded. This guide helps clinicians and coders navigate ICD-10-CM code K59.03 and its pairing with opioid adverse effect codes (T40.x series). Learn how to correctly apply opioid induced constipation ICD 10 codes using validated clinical criteria, best practices, and real-world coding scenarios.
Key Takeaways
- K59.03 is the official opioid induced constipation ICD 10 code used to describe drug-induced constipation related to opioids.
- Must pair with the appropriate T40.x code to denote the specific opioid causing the adverse effect.
- Clinical documentation must show a direct link between opioid use and constipation symptoms.
- Use validated tools such as the Bowel Function Index (BFI) to strengthen coding accuracy.
- Avoid general codes like K59.00 or K59.09—use opioid induced constipation ICD 10 coding for precision and compliance.
- Visual templates and checklists improve accuracy in clinical workflows.
Understanding Opioid‑Induced Constipation ICD 10 Coding
Generic constipation codes like K59.00 or K59.09 are inadequate when symptoms stem from opioid usage. Instead, ICD-10-CM designates K59.03 for opioid induced constipation ICD 10 coding. This diagnosis falls under “drug-induced constipation” in the K59 code family and is the specific code to use when opioid medications are the documented cause.
Opioid induced constipation ICD 10 code usage ensures that medical necessity, pharmacologic management, and payer reviews align with current best practices.
Documentation & Clinical Criteria for K59.03
To apply opioid induced constipation ICD 10 coding, documentation must include:
- Current or recent opioid prescriptions (fentanyl, morphine, oxycodone, etc.)
- Temporal association of constipation onset after opioid initiation (often within 1–2 weeks)
- A Bowel Function Index (BFI) score of ≥28.8 to validate OIC
- Documentation of failed conventional treatments (e.g., laxatives)
When these conditions are met, opioid induced constipation ICD 10 becomes the defensible diagnostic label supported by clinical evidence.

Pairing with T40.x Adverse Effect Codes
Correctly coding opioid induced constipation ICD 10 requires pairing K59.03 with the right T-code to indicate the specific opioid involved. For example:
- T40.4X5A – Adverse effect of synthetic narcotics (e.g., fentanyl, oxycodone)
- T40.2X5A – Other opioids (e.g., morphine)
- Character “A” (initial), “D” (subsequent), or “S” (sequela) should match the encounter context
This pairing is essential. Never use opioid induced constipation ICD 10 K59.03 code alone—it must be accompanied by a corresponding T40.x code.
Coding Pitfalls & Best Practices
Misuse of opioid induced constipation ICD 10 codes is common when documentation is vague. Avoid these pitfalls:
- Using K59.00 or K59.09 instead of the specific K59.03
- Failing to specify the opioid type and duration of use
- Omitting failed laxative therapy or skipping BFI scoring
- Neglecting to pair with a T-code (T40.x)
To ensure proper use of opioid induced constipation ICD 10, train providers to use standardized documentation templates and real-time coding audits.
Coding Scenarios & Examples
Scenario 1:
Patient has been using a fentanyl patch for 3 weeks. Reports constipation, BFI score is 34, and senna has failed.
→ Codes: K59.03 + T40.4X5A (initial encounter)
→ opioid induced constipation ICD 10 application is supported by symptoms, score, and failed treatment.
Scenario 2:
A patient on chronic oxycodone therapy returns for follow-up. BFI score remains elevated.
→ Codes: K59.03 + T40.4X5D (subsequent encounter)
→ Clinical documentation supports continued use of opioid induced constipation ICD 10 coding for reimbursement and ongoing care.

Clinical Management & Impact on Coding
Understanding OIC treatments helps reinforce opioid induced constipation ICD 10 justification. Drugs like methylnaltrexone, naloxegol, and naldemedine—peripherally acting mu-opioid receptor antagonists (PAMORAs)—offer targeted relief without reducing pain control. Including these therapies in documentation further supports the use of K59.03 and validates clinical intent.
Appropriate opioid induced constipation ICD 10 usage directly impacts:
- Prior authorization approvals
- Insurance reimbursement
- Provider performance audits
- Continuity of care
Conclusion
Using the correct Learn opioid induced constipation ICD 10 coding (K59.03 + T40 codes), documentation tips, examples, and coding pitfalls in this expert guide code—K59.03—alongside an appropriate T-code ensures compliance, accuracy, and optimal reimbursement. Coders must confirm documentation of opioid use, validated constipation scoring (BFI), failed interventions, and therapeutic decision-making. With this guide and visual aids, healthcare teams can confidently code OIC cases and support improved patient outcomes and billing integrity.
